Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC074
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-29 11:13
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 1/2+1/4+1/4 old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 39 individuals with a value less than 0.71 were subsequently diagnosed with PD. That is, 92.86% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.71 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 24, 'TN': 18, 'TP': 18, 'FP': 12}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 9, 'TN': 10, 'TP': 33, 'FP': 20}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 30, 'TN': 27, 'TP': 12, 'FP': 3}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 11
timePerCircleMean 15.1055
timePerCircleCoV 0.301541
timePerCircleSlope -0.0482667
meanError 1.83262
tremorFreq 5.56641
tremorRelPower 36.7113
tremorGyroAmpMean 0.0819592
tremorGyroAmpSlope 0.00420214
tremorGyroAmpCoV 0.448879
tremorCoordAmpMean 0.0760069
tremorCoordAmpSlope 0.00405706
tremorCoordAmpCoV 0.410036
tremorAccAmpMean 0.0693708
tremorAccAmpSlope 0.00213674
tremorAccAmpCoV 0.273819
tremorPcRelVar 0.751723
tremorPcX -0.395751
tremorPcY -0.918358

Circle Segment 1

Duration 25.44 s, Accuracy Estimate 2.128 (lower is better)

Circle Segment 2

Duration 17.56 s, Accuracy Estimate 1.619 (lower is better)

Circle Segment 3

Duration 15.4 s, Accuracy Estimate 1.91 (lower is better)

Circle Segment 4

Duration 12.52 s, Accuracy Estimate 1.363 (lower is better)

Circle Segment 5

Duration 12.52 s, Accuracy Estimate 1.787 (lower is better)

Circle Segment 6

Duration 15.64 s, Accuracy Estimate 1.59 (lower is better)

Circle Segment 7

Duration 13.68 s, Accuracy Estimate 2.023 (lower is better)

Circle Segment 8

Duration 11.96 s, Accuracy Estimate 2.073 (lower is better)

Circle Segment 9

Duration 11.8 s, Accuracy Estimate 1.766 (lower is better)

Circle Segment 10

Duration 20.2 s, Accuracy Estimate 1.371 (lower is better)

Circle Segment 11

Duration 9.44 s, Accuracy Estimate 2.529 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 46.24
timePerSpiralCoV 0.144487
timePerSpiralSlope -0.00181661
meanError 1.72875
tremorFreq 5.46875
tremorRelPower 34.0919
tremorGyroAmpMean 0.0587048
tremorGyroAmpSlope -0.000592701
tremorGyroAmpCoV 0.461834
tremorCoordAmpMean 0.0594903
tremorCoordAmpSlope -0.000557165
tremorCoordAmpCoV 0.381247
tremorAccAmpMean 0.0498206
tremorAccAmpSlope 7.60544e-05
tremorAccAmpCoV 0.363846
tremorPcRelVar 0.64317
tremorPcX -0.185935
tremorPcY -0.982562

Spiral Segment 1

Duration 52.52 s, Accuracy Estimate 1.443 (lower is better)

Spiral Segment 2

Duration 35.92 s, Accuracy Estimate 1.576 (lower is better)

Spiral Segment 3

Duration 46.92 s, Accuracy Estimate 1.689 (lower is better)

Spiral Segment 4

Duration 51.56 s, Accuracy Estimate 1.819 (lower is better)

Spiral Segment 5

Duration 44.28 s, Accuracy Estimate 2.116 (lower is better)

Elel

eDurationMean 1.175
eDurationStd 0.417198
eDurationStdnorm 0.355062
eDurationMedian 1.03
eDurationQuartdelta 0.35875
eDurationQuartdeltanorm 0.348301
eDurationKurt 3.77611
eDurationTrenddiff -0.0375
eDurationTrendratio 0.965675
eWidthMean 3.078
eWidthStd 1.02153
eWidthStdnorm 0.331881
eWidthMedian 2.808
eWidthQuartdelta 0.84825
eWidthQuartdeltanorm 0.302083
eWidthKurt 6.95805
eWidthTrenddiff -0.2925
eWidthTrendratio 0.903846
eHeightMean 7.551
eHeightStd 2.22895
eHeightStdnorm 0.295186
eHeightMedian 7.371
eHeightQuartdelta 2.6325
eHeightQuartdeltanorm 0.357143
eHeightKurt 3.48465
eHeightTrenddiff -1.4625
eHeightTrendratio 0.822695
eAspectMean 0.418735
eAspectStd 0.105701
eAspectStdnorm 0.25243
eAspectMedian 0.388235
eAspectQuartdelta 0.0580357
eAspectQuartdeltanorm 0.149486
eAspectKurt 4.08664
eAspectTrenddiff -0.0412065
eAspectTrendratio 0.904222
eSlantMean 0.0561154
eSlantStd 0.158496
eSlantStdnorm 2.82446
eSlantMedian 0.0327869
eSlantQuartdelta 0.227916
eSlantQuartdeltanorm 6.95145
eSlantKurt 2.1609
eSlantTrenddiff 0.161472
eRtopMean 0.738064
eRtopStd 0.197393
eRtopStdnorm 0.267446
eRtopMedian 0.708333
eRtopQuartdelta 0.334121
eRtopQuartdeltanorm 0.4717
eRtopKurt 2.11938
eRtopTrenddiff 0.163945
eRbotMean 0.607627
eRbotStd 0.304777
eRbotStdnorm 0.501586
eRbotMedian 0.545455
eRbotQuartdelta 0.560077
eRbotQuartdeltanorm 1.02681
eRbotKurt 1.72351
eRbotTrenddiff -0.293561
eRrightMean 0.849147
eRrightStd 0.0933434
eRrightStdnorm 0.109926
eRrightMedian 0.851852
eRrightQuartdelta 0.100977
eRrightQuartdeltanorm 0.118538
eRrightKurt 2.5736
eRrightTrenddiff 0.0388102
eRleftMean 0.375765
eRleftStd 0.202351
eRleftStdnorm 0.538505
eRleftMedian 0.329412
eRleftQuartdelta 0.299885
eRleftQuartdeltanorm 0.910364
eRleftKurt 2.17015
eRleftTrenddiff -0.0410647
lDurationMean 1.30531
lDurationStd 0.338085
lDurationStdnorm 0.259007
lDurationMedian 1.3075
lDurationQuartdelta 0.48
lDurationQuartdeltanorm 0.367113
lDurationKurt 2.86195
lDurationTrenddiff -0.385
lDurationTrendratio 0.737649
lWidthMean 5.69644
lWidthStd 1.44166
lWidthStdnorm 0.253081
lWidthMedian 5.499
lWidthQuartdelta 2.5155
lWidthQuartdeltanorm 0.457447
lWidthKurt 2.3509
lWidthTrenddiff 0
lWidthTrendratio 1
lHeightMean 17.5281
lHeightStd 4.69328
lHeightStdnorm 0.267758
lHeightMedian 16.3215
lHeightQuartdelta 6.552
lHeightQuartdeltanorm 0.401434
lHeightKurt 2.46374
lHeightTrenddiff -1.053
lHeightTrendratio 0.937716
lAspectMean 0.334594
lAspectStd 0.071553
lAspectStdnorm 0.213851
lAspectMedian 0.316414
lAspectQuartdelta 0.0759679
lAspectQuartdeltanorm 0.24009
lAspectKurt 4.21796
lAspectTrenddiff 0.044289
lAspectTrendratio 1.14279
lSlantMean 0.192376
lSlantStd 0.0873041
lSlantStdnorm 0.45382
lSlantMedian 0.219962
lSlantQuartdelta 0.10871
lSlantQuartdeltanorm 0.494225
lSlantKurt 2.87267
lSlantTrenddiff 0.0836158
lRtopMean 0.854537
lRtopStd 0.114411
lRtopStdnorm 0.133886
lRtopMedian 0.864329
lRtopQuartdelta 0.152549
lRtopQuartdeltanorm 0.176495
lRtopKurt 2.33199
lRtopTrenddiff 0.0326745
lRbotMean 0.283504
lRbotStd 0.181416
lRbotStdnorm 0.639906
lRbotMedian 0.228299
lRbotQuartdelta 0.116809
lRbotQuartdeltanorm 0.51165
lRbotKurt 4.36537
lRbotTrenddiff -0.0497968
lRrightMean 0.921076
lRrightStd 0.0756311
lRrightStdnorm 0.0821118
lRrightMedian 0.935414
lRrightQuartdelta 0.0910657
lRrightQuartdeltanorm 0.0973534
lRrightKurt 2.41468
lRrightTrenddiff 0.0189721
lRleftMean 0.174148
lRleftStd 0.115068
lRleftStdnorm 0.66075
lRleftMedian 0.122698
lRleftQuartdelta 0.218545
lRleftQuartdeltanorm 1.78116
lRleftKurt 1.67391
lRleftTrenddiff -0.0218077

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

FITTS Short Modified

meanTouchScore 0.856429
sumTouchScores 17.1286
meanMovementTime 0.870789
numTouches 20
undershootPercentage 0
overshootPercentage 35

FITTS Long Modified

meanTouchScore 0.834202
sumTouchScores 10.8446
meanMovementTime 1.3275
numTouches 13
undershootPercentage 0
overshootPercentage 38.4615

ZigZag

numZigzags 5
timePerZigzagMean 34.816
timePerZigzagCoV 0.105975
timePerZigzagSlope -0.052045
meanError 2.66852
tremorFreq 5.76172
tremorRelPower 35.4698
tremorGyroAmpMean 0.0539335
tremorGyroAmpSlope -0.00230036
tremorGyroAmpCoV 0.440136
tremorCoordAmpMean 0.0783952
tremorCoordAmpSlope 8.85155e-05
tremorCoordAmpCoV 0.340343
tremorAccAmpMean 0.108347
tremorAccAmpSlope 9.86766e-05
tremorAccAmpCoV 0.14313
tremorPcRelVar 0.652568
tremorPcX -0.728096
tremorPcY 0.685475

ZigZag Segment 1

Duration 41.04 s, Accuracy Estimate 2.638 (lower is better)

ZigZag Segment 2

Duration 35.2 s, Accuracy Estimate 2.809 (lower is better)

ZigZag Segment 3

Duration 31.8 s, Accuracy Estimate 2.854 (lower is better)

ZigZag Segment 4

Duration 32.92 s, Accuracy Estimate 2.683 (lower is better)

ZigZag Segment 5

Duration 33.12 s, Accuracy Estimate 2.358 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 23.712
timePerZigzagCoV 0.150113
timePerZigzagSlope -0.0484143
zigzagHeightMean 60.5958
zigzagHeightCoV 0.0749734
zigzagHeightSlope -0.0196789
meanError 0.0587092
tremorFreq 5.46875
tremorRelPower 35.9362
tremorGyroAmpMean 0.125918
tremorGyroAmpSlope 0.000277057
tremorGyroAmpCoV 0.60376
tremorCoordAmpMean 0.138532
tremorCoordAmpSlope 0.001982
tremorCoordAmpCoV 0.54825
tremorAccAmpMean 0.102176
tremorAccAmpSlope 0.0025423
tremorAccAmpCoV 0.530734
tremorPcRelVar 0.828685
tremorPcX 0.569169
tremorPcY 0.822221

ZigZag Offset Segment 1

Duration 28.28 s, Accuracy Estimate 0.057 (lower is better)

ZigZag Offset Segment 2

Duration 24.96 s, Accuracy Estimate 0.065 (lower is better)

ZigZag Offset Segment 3

Duration 20.4 s, Accuracy Estimate 0.05 (lower is better)

ZigZag Offset Segment 4

Duration 19.8 s, Accuracy Estimate 0.041 (lower is better)

ZigZag Offset Segment 5

Duration 25.12 s, Accuracy Estimate 0.081 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.79}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.71}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.8181185241213342}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8329085677852364}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4651711150200844}